Data_Sheet_1_The Effect of Yoga on the Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.docx

ObjectivesYoga is a mind-body stress-relieving exercise that increases mental and physical health, which may have a role in the improvement of metabolic disorders. The present study has reviewed the effect of yoga on lipid profiles as a systematic review and meta-analysis.
MethodsWe evaluated the available randomized controlled trials on the effects of yoga-based programs, and lipid profiles by searching PubMed/Medline, Scopus, Web of Science, and the Cochrane central register of control trials up to January 2022. Both fixed and random effect analyses were used to find the relationships. Subgroup analysis was performed based on the continent, duration of the included studies, gender, and health condition of participants to discover the sources of heterogeneity.
ResultFifty-three studies were included in the current systematic review and meta-analysis with a total sample size of 13,191. There was a striking association between yoga and total cholesterol (−10.31 mg/dl; 95% CI: −14.16, −6.45; I2 = 82.5%, P < 0.001), low-density lipoprotein cholesterol (−8.64 mg/dl; 95% CI: −12.03, −5.25; I2 = 75.0%, P < 0.001), high-density lipoprotein cholesterol (1.98 mg/dl; 95% CI: 0.81, 3.14; I2 = 91.6%, P < 0.001), triglycerides (−13.50 mg/dl; 95% CI: −20.09, −6.92; I2 = 90.7%, P < 0.001) and very low-density lipoprotein (−3.94 mg/dl; 95%CI: −6.31, −1.56; I2 = 72.2%, P < 0.001).
ConclusionIt seems yoga interventions had a substantial effect on lipid profiles, however, more qualified trials or cohort studies are needed to conclude exactly.

研究目的：瑜伽是一种身心兼修的减压运动，可提升个体的心理与生理健康水平，或在代谢紊乱的改善中发挥潜在作用。本研究作为一项系统综述（systematic review）与元分析（meta-analysis），探讨了瑜伽对血脂谱的影响。

研究方法：本研究通过检索PubMed/Medline、Scopus、Web of Science以及Cochrane对照试验中央注册库截至2022年1月的相关文献，评估了现有关于瑜伽干预方案与血脂谱关联的随机对照试验（randomized controlled trial）。研究采用固定效应与随机效应模型分析二者的相关性，并基于研究开展的大洲、纳入研究的干预时长、受试者性别以及参与者健康状况开展亚组分析，以明确异质性来源。

研究结果：本次系统综述与元分析共纳入53项研究，总样本量达13191例。分析结果显示，瑜伽干预与多项血脂指标的改善存在显著关联：总胆固醇水平降低10.31 mg/dl（95%置信区间：-14.16, -6.45；I²=82.5%，P < 0.001），低密度脂蛋白胆固醇水平降低8.64 mg/dl（95%置信区间：-12.03, -5.25；I²=75.0%，P < 0.001），高密度脂蛋白胆固醇水平升高1.98 mg/dl（95%置信区间：0.81, 3.14；I²=91.6%，P < 0.001），甘油三酯水平降低13.50 mg/dl（95%置信区间：-20.09, -6.92；I²=90.7%，P < 0.001），极低密度脂蛋白胆固醇水平降低3.94 mg/dl（95%置信区间：-6.31, -1.56；I²=72.2%，P < 0.001）。

研究结论：瑜伽干预对血脂谱似乎具有显著的改善效果，但仍需开展更多高质量随机对照试验或队列研究（cohort study）以得出更为确切的结论。