Brain Areas During Stressful Contexts Predict Anxious Temperament

Regions where anxious temperament was significantly (p<.05, two-tailed multi-FDR corrected) correlated with regional brain metabolism in the Alone (ALN) and No-Eye-Contact (NEC) conditions separately, and in both the ALN and NEC conditions combined with a logical AND conjunction analysis (ALN and NEC). Regions are presented with the direction of the correlation, brain regions involved, volume and hemisphere of cluster. We also report the local maxima for each anatomical region within the statistical cluster with its corresponding t-value and location (in millimeters relative to the anterior commisure). * Although the Anterior Temporal Pole may be important for the understanding of anxious temperament, we do not interpret these findings because there are highly metabolic muscles that border this portion of the brain that may influence the measures of brain metabolism. Therefore, in accordance with Drevets et al.,[34], we report but refrain from interpreting this finding.

本研究明确了在单独独处（Alone, ALN）与无眼神接触（No-Eye-Contact, NEC）两种实验条件下，以及将两种条件通过逻辑与（AND）联合分析得到的合并条件中，焦虑气质与大脑局部代谢水平存在显著相关性（双侧检验经多重错误发现率（False Discovery Rate, FDR）校正后p<0.05）的脑区。报告将涵盖相关性方向、所涉及的脑区、聚类体积与半球信息。此外，我们还将给出每个统计聚类内各解剖区域的局部峰值坐标，及其对应的t值与相对于前连合的毫米级空间坐标。
* 尽管颞极前部（Anterior Temporal Pole）可能对焦虑气质的认知解析具有重要价值，但鉴于该脑区毗邻高代谢的肌肉组织，可能会干扰脑代谢测量结果，因此我们未对该结果进行解读。遵照Drevets等人[34]的研究规范，本研究仅报告该发现而不做阐释。