Table 1_Exploring the therapeutic potency of cryptotanshinone in cervical cancer: a multi-omics and network pharmacology approach.docx

IntroductionCervical cancer remains a significant challenge in oncology with an escalating demand for novel therapeutic strategies that can navigate the complexities of its pathophysiology. This study elucidated the antineoplastic effects of cryptotanshinone, a derivative of danshen (Salvia miltiorrhiza), a herb widely utilized in traditional Chinese medicine practices.
MethodsEmploying a comprehensive multi-omics approach, including transcriptomic, proteomic, and bioinformatics analyses, we investigated the potential effects of cryptotanshinone on cervical cancer through data mining and computational analysis.
Results and DiscussionOur results demonstrated that the potential of cryptotanshinone to disrupted cancer cell proliferation and induced apoptosis may be ascribed to its modulation of gene expression and interaction with specific protein networks. Furthermore, network pharmacology and pathway enrichment analyses identified critical hubs and signaling pathways, suggesting a multi-targeted mechanism of action. Furthermore, the establishment of a prognostic model, which is founded upon differentially expressed genes linked to cryptotanshinone treatment, underscores its promising role as both a prognostic biomarker and a therapeutic agent. These insights pave the way for the integration of cryptotanshinone into therapeutic regimens, offering a promising avenue for enhancing the efficacy of cervical cancer treatment and patient outcomes.

引言 宫颈癌仍是肿瘤学领域的重大难题，临床对能够应对其病理生理学复杂机制的新型治疗策略需求日益增长。本研究阐明了隐丹参酮（cryptotanshinone）的抗肿瘤作用：隐丹参酮是丹参（Salvia miltiorrhiza）的提取物，而丹参是中医药中应用广泛的草本药材。
方法 本研究采用涵盖转录组学、蛋白质组学及生物信息学分析的多组学综合研究策略，通过数据挖掘与计算分析，探究了隐丹参酮对宫颈癌的潜在作用。
结果与讨论 研究结果显示，隐丹参酮可抑制宫颈癌细胞增殖并诱导细胞凋亡，其作用机制可能与其调控基因表达、与特定蛋白网络相互作用有关。此外，通过网络药理学与通路富集分析，本研究鉴定出关键靶点枢纽与信号通路，提示其作用机制具有多靶点特性。进一步基于隐丹参酮处理后差异表达基因构建的预后模型，证实了其兼具预后生物标志物与治疗药物的潜在应用价值。本研究结果为将隐丹参酮纳入宫颈癌治疗方案提供了理论支撑，为提升宫颈癌治疗疗效、改善患者预后开辟了新的可行方向。