Data for: Molecular and clinicopathological differences between depressed and protruded T2 colorectal cancer

Background
Colorectal cancer (CRC) can be classified into four consensus molecular subtypes (CMS) according to genomic aberrations and gene expression profiles. CMS is expected to be useful in predicting prognosis and selecting chemotherapy regimens. However, there are still no reports on the relationship between the morphology and CMS.
Methods
This retrospective study included 55 subjects with T2 CRC undergoing surgical resection, of whom 30 had the depressed type and 25 the protruded type. In the classification of the CMS, we first defined cases with deficient mismatch repair as CMS1. And then, CMS2/3 and CMS4 were classified using an online classifier developed by Trinh et al. The staining intensity of CDX2, HTR2B, FRMD6, ZEB1, and KER and the percentage contents of CDX2, FRMD6, and KER are input into the classifier to obtain automatic output classifying the specimen as CMS2/3 or CMS4.
Results
According to the results yielded by the online classifier, of the 30 depressed-type cases,...

背景
结直肠癌（Colorectal cancer, CRC）可根据基因组异常及基因表达谱分为四种共识分子亚型（consensus molecular subtypes, CMS）。CMS有望用于预测预后及选择化疗方案，但目前尚无关于形态学与CMS关系的报道。

方法
本回顾性研究纳入55例接受手术切除的T2期CRC患者，其中凹陷型30例，隆起型25例。CMS分类中，首先将错配修复缺陷（deficient mismatch repair）病例定义为CMS1；随后采用Trinh等人开发的在线分类器对CMS2/3与CMS4进行分类。将CDX2、HTR2B、FRMD6、ZEB1及KER的染色强度，以及CDX2、FRMD6、KER的百分比含量输入分类器，即可自动输出标本的CMS2/3或CMS4分类结果。

结果
根据在线分类器得出的结果，在30例凹陷型病例中，...