Cornea resistance factor GWAS in the UK Biobank

Summary statistics from the genome-wide association study (GWAS) of cornea resistance factor (CRF) of 76,029 UK Biobank samples of British ancestry obtained through the application number 19655. The CRF analysis was performed on the average of the left and right eye measurements. Any outliers (i.e. CRF greater than population mean difference + 3 standard deviations) were removed. Further phenotypic filtering was applied by removing samples linked to, or self-reporting, ocular conditions that could affect the measurements accuracy such as eye surgery, refractive laser surgery, cataract surgery, glaucoma high pressure surgery or laser treatment, corneal graft surgery, eye injury , keratoconus or cornea disorders. A total of 102490 samples were kept. Using the genetic quality control of the UK Biobank the 76318 samples of British ancestry with imputed data failing heterozygosity or/and missingness, or having a mismatch between self-reported and genotype-derived gender or showing putative sex chromosome aneuploidy as well as individuals who have withdrawn from the study at the time of analysis were removed. An total of N-76029 were included in the GWAS. The GWAS was performed on common and low-frequency (MAF > 0.5%) well imputed (INFO > 0.6) variants using a linear mixed model accounting for population structure and (cryptic) relatedness, implemented in the software BOLT_LMM v1.3. Covariates fitted in the model were: age, sex, assessment centre, genotyping array, genotyping batch and the 20 first principal components of ancestry provided by the UK Biobank.

通过申请编号19655获取的76,029名英国血统英国生物银行样本的角膜阻力因子（CRF）全基因组关联研究（GWAS）汇总统计数据。CRF分析基于左右眼测量值的平均值进行。所有离群值（即CRF值大于总体均值加3个标准差）均已被剔除。进一步的表型过滤通过剔除与以下可能影响测量准确性的眼部疾病相关或自我报告患有这些疾病的样本实现：眼部手术、屈光激光手术、白内障手术、青光眼高压手术或激光治疗、角膜移植手术、眼外伤、圆锥角膜或角膜疾病。共保留102490个样本。利用英国生物银行的遗传质量控制标准，剔除了76318名英国血统样本中填充数据不符合杂合性或/和缺失率要求、自我报告性别与基因型推导性别不一致、存在疑似性染色体非整倍体，以及在分析时已退出研究的个体。最终共有76029个样本纳入GWAS分析。