Human gut metagenome in patients with chronic intestinal pseudo-obstruction (CIPO). Human gut metagenome

Chronic intestinal pseudo-obstruction (CIPO) is a severe form of intestinaldysmotility, yet little is known about the gut microbiome and metabolome of affected patients. Wehypothesized that the CIPO microbiota might promote the production of metabolites that furtherthe hallmark symptoms.

慢性假性肠梗阻（Chronic intestinal pseudo-obstruction, CIPO）是一类严重的肠动力障碍性疾病，但目前学界对受累患者的肠道微生物组（gut microbiome）与代谢组（metabolome）的认知仍较为匮乏。我们提出假说：CIPO患者的肠道菌群可能会促进相关代谢物的生成，进而加剧该病的典型症状。