Clonal architecture and genomic features of smoking versus non-smoking oncogene-driven East-Asian non-small cell lung cancer

Unlike smoking-related non-small cell lung cancers (NSCLC), oncogene-driven tumors are characterized by low mutational burdens and complex genomic landscapes. However, the clonal architecture and genomic landscape of the oncogene-driven tumors in smokers remains unknown. Here, we investigate the impact of tobacco smoking on the genomic and transcriptomic alterations in the context of oncogene-driven NSCLC.EGA study EGAS00001006942

与吸烟相关的非小细胞肺癌（non-small cell lung cancer, NSCLC）不同，癌基因驱动型肿瘤以低突变负荷与复杂的基因组图谱为特征。然而，吸烟者体内癌基因驱动型肿瘤的克隆结构与基因组图谱尚未明确。本研究探究了烟草吸烟在癌基因驱动型非小细胞肺癌背景下对基因组与转录组改变的影响。本研究相关数据来自欧洲基因组表型库（European Genome-phenome Archive, EGA）的研究项目EGAS00001006942