Identification of potential proteins bind to TGF-β receptor II in hepatic stellate cells

Activated hepatic stellate cells/myofibroblasts induced by TGF-β within the hepatic microenvironment are crucial determinants for cell growth and liver metastasis of colorectal cancer. Notably, TGF-β receptor II serves as the initiator of the received signal, and its membrane localization, internalization, degradation, and trafficking play a decisive role in determining the duration and intensity of TGF-β/SMAD signaling. This study aimed to identify the proteins that interact with TGF-β receptor II and clarify the underlying mechanisms of myofibroblastic activation of HSCs.肝微环境中由转化生长因子-β（TGF-β）诱导活化的肝星状细胞/肌成纤维细胞，是结直肠癌细胞生长及肝转移的关键决定因素。值得注意的是，转化生长因子-β受体II（TGF-β receptor II）作为信号接收的起始因子，其膜定位、内化、降解及转运过程，对TGF-β/SMAD信号通路的持续时间和强度起决定性作用。本研究旨在鉴定与TGF-β受体II相互作用的蛋白质，并阐明肝星状细胞（HSCs）肌成纤维细胞活化的潜在机制。