Modelling human pre-gastulation development by 3D culture of blastoids generated from the primed-to-naive transitioning intermediates [scRNA-seq]

Our study provides an alternative strategy to generate human blastoids and model early embryogenesis up to pre-gastrulation stage, facilitating the insights into human embryonic development Single cell transcription profiling of blastoid generated from intermediates during human primed-to-naïve transition process .

本研究开发了一种生成人类类囊胚（blastoids）的替代策略，并可构建直至原肠胚形成前阶段的早期胚胎发生模型，有助于深入解析人类胚胎发育机制。此外，本研究对人类始发态-原始态（primed-to-naïve）转换过程中中间体细胞所产生的类囊胚进行了单细胞转录谱分析。