Table 1_Exploring research trends and hotspots in PI3K/Akt signaling pathway in ischemic stroke: a bibliometric analysis.xlsx

ObjectiveThis study explores potential therapeutic strategies by determining the current research status, hotspots, and development trends through bibliometric analysis of the PI3K/Akt in ischemic stroke (IS).
MethodsWe searched the Web of Science Core Collection for publications on IS and the PI3K/Akt pathway, covering January 1, 2010, to December 31, 2024. VOSviewer and CiteSpace software were used to analyze research hotspots and cutting-edge topics in the field and generate visual maps of relevant countries, institutions, authors, journals, keywords, and references.
ResultsA total of 635 publications were analyzed. The number of publications indicates a steady annual increase in research output. China, Capital Medical University, and Wang Lei were identified as the most prolific country, institution, and author, respectively. The top three contributing journals were Brain Research, Journal of Ethnopharmacology, and Frontiers in Pharmacology. Autophagy, microglia and neuroinflammation, bioinformatics approaches, and traditional Chinese medicine (TCM) are not only current research areas but also important trends for future research. Notably, targeting IS with TCM holds significant potential for translating basic research findings into clinical applications.
ConclusionThis bibliometric analysis provides an in-depth overview of research on the PI3K/Akt pathway in IS, revealing current research status, hotspots, and future research trends. This will provide valuable guidance and direction for developing novel therapeutic strategies targeting this pathway.

研究目的 本研究通过对缺血性脑卒中（ischemic stroke, IS）领域中PI3K/Akt通路开展文献计量学分析，明确当前研究现状、研究热点与发展趋势，以此探索潜在的治疗策略。研究方法 本研究检索了2010年1月1日至2024年12月31日期间，Web of Science核心合集收录的与缺血性脑卒中及PI3K/Akt通路相关的文献。采用VOSviewer与CiteSpace两款软件，对该领域的研究热点与前沿主题展开分析，并绘制相关国家、机构、作者、期刊、关键词及参考文献的可视化图谱。研究结果 本研究共分析了635篇相关文献。文献发表量呈逐年稳步增长态势。中国、首都医科大学及王磊分别为该领域发文量最高的国家、机构与作者。发文量排名前三的期刊依次为《Brain Research》、《Journal of Ethnopharmacology》及《Frontiers in Pharmacology》。自噬、小胶质细胞与神经炎症、生物信息学方法及中医药（traditional Chinese medicine, TCM）不仅是当前的研究热点领域，亦是未来研究的重要方向。值得注意的是，利用中医药靶向治疗缺血性脑卒中，在将基础研究成果转化为临床应用方面具备巨大潜力。研究结论 本文献计量学分析对缺血性脑卒中领域中PI3K/Akt通路的相关研究进行了全面深入的梳理，明晰了当前研究现状、热点方向与未来发展趋势，可为靶向该通路开发新型治疗策略提供极具价值的指导与方向。