Total Synthesis of (+)-Decursivine

The first asymmetric synthesis of natural indole alkaloid (+)-decursivine was accomplished. The key step involves the PIFA-mediated intramolecular [3 + 2] cycloaddition of 5-hydroxytryptophan with a substituted cinnamamide in a highly diastereoselective manner.

天然吲哚生物碱(+)-decursivine的首例不对称合成已成功完成。该合成的关键步骤为：以PIFA介导5-羟色氨酸（5-hydroxytryptophan）与取代肉桂酰胺（substituted cinnamamide）发生高非对映选择性的分子内[3+2]环加成反应。