Additional file 1 of Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus

Additional file 1: Table S1. DAP1-SLE association results based on Immunochipv.1. Table S2. List of sequencing variants in DAP1 gene region-European cohort. Table S3. 19 SLE associated DAP1 variants used for haplotype analysis. Table S4. List of variants in African-American and Chinese cohort. Table S5. Cochran-Mantel-Haenszel test result on SNPs. Table S6. DAP1 haplotype association analysis results. Table S7. Trans-ethnic analysis by Cochran-Mantel-Haenszel and MR-MEGA program. Table S8. Diplotypes analysis in Caucasian data. Table S9. Potentially regulatory variant annotations. Table S10- eQTL effects of SLE associated variants. Table S11. Lymphoblastoid Cell Lines (LCL) used in study. Table S12. PBMCs RNA-Seq analysis. Table S13. Reactome pathway analysis. Table S14. Autoantibody data. Table S15. List of participating institutions and investigators.

附加文件1：补充表S1。基于免疫芯片v.1（Immunochipv.1）的DAP1与系统性红斑狼疮（Systemic Lupus Erythematosus, SLE）关联分析结果。补充表S2。欧洲队列中DAP1基因区域测序变异体列表。补充表S3。用于单倍型分析的19个SLE相关DAP1变异体。补充表S4。非裔美国人及中国人群队列中的变异体列表。补充表S5。单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的科克兰-曼特尔-海森（Cochran-Mantel-Haenszel）检验结果。补充表S6。DAP1单倍型关联分析结果。补充表S7。采用科克兰-曼特尔-海森法及MR-MEGA程序开展的跨种族分析结果。补充表S8。高加索人群数据中的双体型分析结果。补充表S9。潜在调控变异体注释信息。补充表S10。SLE相关变异体的表达数量性状位点（expression Quantitative Trait Locus, eQTL）效应。补充表S11。本研究使用的淋巴母细胞样细胞系（Lymphoblastoid Cell Lines, LCL）。补充表S12。外周血单个核细胞（Peripheral Blood Mononuclear Cells, PBMC）RNA测序分析。补充表S13。Reactome通路分析。补充表S14。自身抗体数据。补充表S15。参与本研究的机构及研究者列表。