Support the data for "Modulation of microglial state for neuroplasticity and function preservation in transgenic mouse models of Alzheimer’s disease"

This dataset is used to support the thesis of Modulation of microglial state for neuroplasticity and function preservation in transgenic mouse models of Alzheimer’s disease''.  There are several folders in the dataset: the first part of this data is to explore whether the LBE is a good candidate for AD by regulating the microglia state in central neural systems. Subfolder 1 is about LBE on IMG cell line exposure to amyloid-beta, subfolder 2 is for the brain, subfolder 3 is for the spinal cord, and subfolder 4 is for the retina. These supported data further proved the functional effects in different parts of CNS.
The next objective is to identify the microglia DNA-based extracellular traps induced by amyloid-beta and investigate the effects of destroying MiETs by DNase treatment in the improvement of plasticity and function preservation for AD, which is supported by subfolder 5.

本数据集旨在支持关于通过调节阿尔茨海默病转基因小鼠模型的胶质细胞状态来促进神经可塑性和功能保留的论点。数据集中包含数个文件夹：数据集的第一部分旨在探讨LBE是否能够通过调节中枢神经系统的胶质细胞状态成为阿尔茨海默病的理想候选药物。子文件夹1涉及LBE对amyloid-beta暴露的IMG细胞系的处理，子文件夹2针对大脑，子文件夹3针对脊髓，子文件夹4针对视网膜。这些支持性数据进一步证实了中枢神经系统不同部位的函数效应。下一目标为识别由amyloid-beta诱导的基于胶质细胞DNA的细胞外陷阱，并研究通过DNase处理破坏MiETs对改善阿尔茨海默病的可塑性和功能保留的影响，这些研究得到了子文件夹5的支持。