Probiotics improve acute gastrointestinal dysfunction in patients undergoing cardiopulmonary bypass surgery

Acute gastrointestinal injury (AGI) after cardiopulmonary bypass (CPB) is one of the signs for poor prognosis. This study aimed to investigate the effect of preoperative probiotics supplementation on AGI. In this double-blind randomized controlled trial, patients undergoing heart valve replacement (HVR) with CPB were randomly assigned to receive either a probiotic (Lac group) or placebo (Placebo group). The probiotic was given daily, for seven days before surgery. We demonstrated that preoperative supplementation of probiotics can improve the recovery of patients after CPB surgery by preventing acute gastrointestinal injury. Cardiac Surgery Score, and the duration of CPB ≥ 132 min are independent risk factors for the occurrence of AGI. In contrast, probiotics is a preventive factor for the occurrence of AGI. There was gut microbiota imbalance in patients who underwent HVR with CPB. The 16s rRNA showed that there was a difference in gut microbiota between two groups.

体外循环（cardiopulmonary bypass, CPB）术后急性胃肠道损伤（acute gastrointestinal injury, AGI）是预后不良的表现之一。本研究旨在探讨术前益生菌补充对AGI的影响。本项双盲随机对照试验中，接受体外循环下心脏瓣膜置换术（heart valve replacement, HVR）的患者被随机分配至益生菌组（Lac组）或安慰剂组。益生菌于术前每日给药，连续7天。研究证实，术前补充益生菌可通过预防急性胃肠道损伤，改善体外循环术后患者的康复结局。心脏手术评分、体外循环时长≥132分钟是AGI发生的独立危险因素；与之相对，益生菌是AGI发生的保护性因素。接受体外循环下心脏瓣膜置换术的患者存在肠道菌群失调，16S rRNA检测结果显示两组患者的肠道菌群存在差异。