Additional file 2 of An epigenome-wide association study of insulin resistance in African Americans

Additional file2. Table S1. List of CpG sites within the HOXA5 DMR; Table S2. Previously reported EWAS for insulin resistance; Table S3. DMPs reported in previous insulin resistance EWAS; Table S4. Association between candidate CpG sites reported in previous studies and HOMA-IR in African American men.Table S5. Summary statistics from the main HOMA-IR analysis in African American men for candidate CpG sites; Table S6. Candidate probes that successfully replicated in African American men; Table S7a. Chromatin states of top 100 DMPs associated with insulin resistance in African American men from clusterProfiler; Table S7b. Chromatin states of top 100 DMPs associated with insulin resistance in African American men from the EWAS Toolkit; Table S8. Gene function and associated phenotypes in GWAS catalog and GeneCards; Table S9A. Traits associated with the three identified DMPs (annotated genes) in the EWAS catalog; Table S9B. Traits associated with genes in the 500kb vicinity of HOXA5, OSR1, and ST18 in the EWAS catalog; Table S10. R packages used in the analyses.

附加文件2。附表S1：HOXA5差异甲基化区域（Differentially Methylated Region, DMR）内的CpG位点（CpG site）列表；附表S2：既往发表的胰岛素抵抗相关全表观基因组关联研究（Epigenome-Wide Association Study, EWAS）汇总；附表S3：既往胰岛素抵抗相关全表观基因组关联研究中报道的差异甲基化位点（Differentially Methylated Position, DMP）列表；附表S4：既往研究报道的候选CpG位点与非洲裔美国男性稳态模型评估胰岛素抵抗指数（Homeostatic Model Assessment for Insulin Resistance, HOMA-IR）的关联分析结果；附表S5：针对非洲裔美国男性候选CpG位点的核心HOMA-IR分析汇总统计量；附表S6：在非洲裔美国男性中成功重复验证的候选探针；附表S7a：基于clusterProfiler分析得到的、与非洲裔美国男性胰岛素抵抗相关的前100个差异甲基化位点的染色质状态；附表S7b：基于EWAS Toolkit分析得到的、与非洲裔美国男性胰岛素抵抗相关的前100个差异甲基化位点的染色质状态；附表S8：全基因组关联研究目录（Genome-Wide Association Study Catalog, GWAS Catalog）与GeneCards数据库收录的基因功能及相关表型；附表S9A：全表观基因组关联研究目录中收录的3个已鉴定差异甲基化位点（对应注释基因）相关的性状；附表S9B：全表观基因组关联研究目录中收录的、位于HOXA5、OSR1和ST18基因上下游500kb区域内的相关基因所对应的性状；附表S10：本分析所使用的R软件包列表。