Additional file 1 of DNA methylation of FKBP5 in South African women: associations with obesity and insulin resistance

Additional file 1: Figure S1. Sensitivity of pyrosequencing assays used to interrogate GR and FKBP5. Standard curves for GR CpG-226 to CpG-217 (A), GR CpG-209 to CpG-202 (B), FKBP5 CpG -585 to CpG-573 (C) and FKBP5 CpG542 and CpG543 (D). Table S1. Correlation between DNA methylation and cardiometabolic risk factors. Data expressed as the β-coefficient (p-value) adjusted for ethnicity, socioeconomic status and *alcohol consumption. Abbreviations: ASAT, abdominal subcutaneous adipose tissue; BMI, body mass index; CRP, c-reactive protein; GSAT, gluteal subcutaneous adipose tissue; HOMA-IR, Homeostatic model assessment-insulin resistance; SI, insulin sensitivity index; WC, waist circumference. Table S2. Correlation between FKBP5 mRNA levels and cardiometabolic risk factors. Data expressed as the Spearman’s r-coefficient (p-value). Abbreviations: ASAT, abdominal subcutaneous adipose tissue; BMI, body mass index; CRP, c-reactive protein; GSAT, gluteal subcutaneous adipose tissue; HOMA-IR, Homeostatic model assessment-insulin resistance; SES, socioeconomic status, SI, insulin sensitivity index; WC, waist circumference.

附加文件1：图S1。本研究用于检测GR与FKBP5的焦磷酸测序（pyrosequencing）检测方法的灵敏度，包含GR基因CpG-226至CpG-217区域（图A）、GR基因CpG-209至CpG-202区域（图B）、FKBP5基因CpG-585至CpG-573区域（图C）以及FKBP5基因CpG542与CpG543区域（图D）的标准曲线。

表S1：DNA甲基化与心血管代谢危险因素的相关性。数据以校正种族、社会经济地位及*饮酒量后的β系数（p值）表示。
缩写说明：ASAT（abdominal subcutaneous adipose tissue，腹部皮下脂肪组织）；BMI（body mass index，体质量指数）；CRP（c-reactive protein，C反应蛋白）；GSAT（gluteal subcutaneous adipose tissue，臀下皮下脂肪组织）；HOMA-IR（Homeostatic model assessment-insulin resistance，稳态模型胰岛素抵抗指数）；SI（insulin sensitivity index，胰岛素敏感性指数）；WC（waist circumference，腰围）。

表S2：FKBP5 mRNA表达水平与心血管代谢危险因素的相关性。数据以斯皮尔曼r系数（Spearman’s r-coefficient）（p值）表示。
缩写说明：ASAT（abdominal subcutaneous adipose tissue，腹部皮下脂肪组织）；BMI（body mass index，体质量指数）；CRP（c-reactive protein，C反应蛋白）；GSAT（gluteal subcutaneous adipose tissue，臀下皮下脂肪组织）；HOMA-IR（Homeostatic model assessment-insulin resistance，稳态模型胰岛素抵抗指数）；SES（socioeconomic status，社会经济地位）；SI（insulin sensitivity index，胰岛素敏感性指数）；WC（waist circumference，腰围）。