Platinum(II) Chloride-Catalyzed Stereoselective Domino Enyne Isomerization/Diels−Alder Reaction

Chiral 1,6-enynes were prepared via Ir-catalyzed allylic substitutions. Their platinum(II) chloride-catalyzed domino enyne isomerization/Diels−Alder reaction provided stereoselective access to complex heterocycles. Very high diastereoselectivity was induced by a chirality center of the enyne.

通过铱催化的烯丙基取代反应制备了手性1,6-烯炔（chiral 1,6-enynes）。经氯化铂(II)催化的多米诺烯炔异构化/狄尔斯-阿尔德（Diels−Alder）反应，可实现复杂杂环的立体选择性合成。该烯炔的手性中心可诱导出极高的非对映选择性。