Cytotoxic T-cell Signaling

The Cytotoxic T-cell Signaling network depicts the causal mechanisms that are activated in CD8+ cytotoxic T-cells following T-cell receptor (TCR) ligation. Expanding on these processes, the network highlights the chemokines secreted by macrophages and dendritic cells, as well as the cognate T-cell receptors, involved in mediating T-cell recruitment to compromised lung tissue during COPD development.

细胞毒性T细胞信号网络（Cytotoxic T-cell Signaling network）呈现了T细胞受体（TCR）发生配体结合后，CD8+细胞毒性T细胞内被激活的因果调控机制。在此基础上，该网络进一步阐释了慢性阻塞性肺疾病（COPD）发生发展过程中，介导T细胞向受损肺组织募集的相关分子：包括巨噬细胞与树突状细胞分泌的趋化因子，以及同源T细胞受体。