MRSA UKM 2003 strain MRSA_P14. Staphylococcus aureus strain:MRSA_P14

Whole genome sequencing (WGS) was applied retrospectively to an unusual spike in MRSA in two ICUs over the course of 4 weeks. While the epidemiological investigation concluded that there were two separate clusters, each associated with one ICU, spa typing data suggested a single clonal cluster (all cases shared spa type t001). Standardized gene sets were used to extract an allele-based profile for typing, and an antibiotic resistance and toxin gene profile.

研究人员针对4周内两家重症监护病房（ICU）中耐甲氧西林金黄色葡萄球菌（MRSA）的异常暴发，回顾性地开展了全基因组测序（WGS）分析。尽管流行病学调查判定存在两起独立的感染聚集事件，且每起均关联至一家重症监护病房，但spa分型（spa typing）数据显示，所有病例均共享spa型别t001，实为单一克隆簇。本研究采用标准化基因集，提取了用于分型的等位基因谱以及抗生素耐药性与毒素基因谱。