Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular Communication. Single Cell Transcriptomic Analysis in a Mouse Model of Barth Syndrome Reveals Cell-Specific Alterations in Gene Expression and Intercellular Communication

To identify novel, cell-specific, pathological pathways that mediate heart dysfunction in Barth Syndrome, we performed single-nucleus RNA-sequencing (snRNA-seq) on wild type and Tafazzin-knockout mouse hearts. Overall design: Four wild type and four Tafazzin-knockout mouse hearts were sampled to analyze using snRNA-seq.

为鉴定介导巴尔特综合征（Barth Syndrome）心脏功能异常的新型细胞特异性病理通路，我们对野生型（wild type）与Tafazzin基因敲除（Tafazzin-knockout）小鼠心脏开展了单细胞核RNA测序（single-nucleus RNA-sequencing, snRNA-seq）。总体实验设计：采集4例野生型与4例Tafazzin基因敲除小鼠心脏样本，通过snRNA-seq进行分析。