Analysis of mid-colon and mid-jejunum mucosa from C57BL/6J wild-type mice exposed to 5-fluorouracil (5FU)

ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitro-in vivo translation in toxicological studies, as well as translation between non-clinical species (such as rat and mouse) and humans. This experimental setup aimed to investigate the injury dynamics underlying repeated exposure to two doses of 5-FU (20 and 50 mg/kg), sampled at multiple time points (6, 24, 96 and 144h). The 144h time point comprises of recovery samples (i.e., 48h following the last dosing with 5-FU). This dataset is part of the TransQST collection.药物不良反应（adverse drug reactions，简称ADRs）是临床场景中导致治疗中断或给药方案调整的主要原因之一。化疗诱导的不良反应较为常见，尤以胃肠道相关不良反应为突出。TransQST（transqst.org）的核心目标之一，是提升毒理学研究中的体外-体内转化效率，以及非临床实验物种（如大鼠、小鼠）与人类之间的实验结果转化。本实验设置旨在探究反复暴露于两种剂量（20 mg/kg与50 mg/kg）的5-FU后的损伤动态特征，并在多个时间节点（6、24、96及144小时）采集样本。其中144小时时间节点的样本为恢复性样本，即末次给予5-FU后48小时采集的样本。本数据集隶属于TransQST数据集集合。