Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F

Described herein is a novel synthetic approach to diptoindonesin G, a highly potent anticancer oligostilbenoid natural product, from pauciflorol F pentamethyl ether through a skeletal reorganization strategy where oxidative cleavage of the indanone ring system of pauciflorol F and sequential cyclization of the key intermediate allowed direct access to the target skeleton.

本文报道了一种以密花树酚F五甲醚（pauciflorol F pentamethyl ether）为起始原料，通过骨架重排策略合成强效抗癌低聚芪类天然产物二波吲哚酮G（diptoindonesin G）的全新合成方法。该策略通过氧化裂解密花树酚F的茚酮环体系，并对关键中间体进行连续环化，可直接构建目标产物的核心骨架。