Antimicrobial wound dressing films containing essential oils and oleoresins of pepper encapsulated in sodium alginate films

ABSTRACT: Medicated wound dressings are important barriers to avoid contamination and, when they contain antimicrobial additives, can be used as treatment for infected wounds. There are several types of polysaccharide materials that serve as matrices for medicated wound dressings, among them, sodium alginate. For the preparation of the films studied in this paper, sodium alginate was employed in combination with essential oils/oleoresins (EO/OL) of six peppers that are commonly used in cooking. The EO/OL were incorporated at three different concentrations (low, intermediate and high). Most of the films prepared had better dispersion of the EO/OL at the intermediate concentration. All films studied in this research were dissolved in water at different rates. The antibacterial activity of the prepared films showed significant results against Escherichia coli, Staphylococcus aureus and Bacillus cereus, and demonstrated that the films studied may be a new alternative for medicated wound dressings.

摘要：药用伤口敷料是避免创口污染的重要屏障，当其添加抗菌添加剂时，还可用于感染性伤口的治疗。可作为药用伤口敷料基质的多糖类材料种类繁多，海藻酸钠（sodium alginate）便是其中之一。本研究中所制备的薄膜，以海藻酸钠为基材，复配了六种常用烹饪用胡椒的精油/油树脂（EO/OL）。上述精油/油树脂分别以低、中、高三种不同浓度掺入薄膜基质中。多数制备得到的薄膜，在中等浓度添加条件下，精油/油树脂的分散效果最优。本研究中所有受试薄膜在水中均表现出不同的溶解速率。所制备薄膜对大肠杆菌（Escherichia coli）、金黄色葡萄球菌（Staphylococcus aureus）及蜡样芽孢杆菌（Bacillus cereus）均表现出显著的抗菌活性，表明该类薄膜有望成为药用伤口敷料的新型备选方案。