Transcriptome of Human Primary Corneal Endothelial Cells with SLC4A11 deficiency

Mutations in the solute-linked carrier family 4 member 11 (SLC4A11) gene are associated with several corneal endothelial dystrophies, in all of which visually significant cornea edema may require corneal transplantation. To elucidate the pathogenesis of SLC4A11 associated corneal endothelial dystrophies, we analyzed the transcriptome of SLC4A11 knock-down primary human corneal endothelium (SLC4A11 KD pHCEnC) and scrambled RNA treated pHCEnC as controls. Overall design: 3 KD vs 3 CTRL

溶质载体家族4成员11（solute-linked carrier family 4 member 11，SLC4A11）基因的突变与多种角膜内皮营养不良相关，此类疾病患者若出现致视力损害的角膜水肿，往往需行角膜移植术。为阐明SLC4A11相关角膜内皮营养不良的发病机制，本研究对SLC4A11基因敲低的原代人角膜内皮细胞（SLC4A11 KD pHCEnC）以及以经乱序RNA处理的原代人角膜内皮细胞为对照的转录组进行了分析。实验整体设计：3组敲低组与3组对照组。