Trem2 prevents adverse pregnancy outcomes induced by Toxoplasma gondii by promoting PPARγ-mediated P-STAT6 signaling

Decidual macrophages (DMs), required for the maintenance of a successful pregnancy, are vital target cells for Toxoplasma gondii (T. gondii) during adverse pregnancy induced by T. gondii. Triggering receptor expressed on myeloid cells 2 (Trem2) is a functional immune receptor on the surface of DMs, governing cell survival and phagocytosis.

蜕膜巨噬细胞（Decidual macrophages, DMs）是维持妊娠成功所必需的细胞，同时也是刚地弓形虫（Toxoplasma gondii, T. gondii）诱导不良妊娠过程中的关键靶细胞。髓系细胞触发受体2（Triggering receptor expressed on myeloid cells 2, Trem2）是蜕膜巨噬细胞表面的功能性免疫受体，可调控细胞存活与吞噬功能。