Overview of clinical parameters associated to the diabetic patients of each cluster (based on kmeans clustering considering data of both groups).

p value following Bonferroni correction = 0.05/26 = 0.002, *Pairwise Fisher exact test for number of diabetic feet: cluster 2 and 3 significantly different, **Pairwise Fisher exact test for feet men/women: cluster 2 significant different from 3 and 4, FDS: Foot Deformity Score: 6 point scale (1 point for each characteristic: small muscle wasting, bony prominence, prominent metatarsal heads, hammer/claw toes, limited joint mobility, charcot foot deformity). (Charcot foot was an exclusion criteria for this study, limited joint mobility not considered here (prayer sign)). Pedal pulses: palpation of the dorsalis pedis and tibial pulses. Sens Monofil 10 g: sensation of the 10 g monofilament (6 point scale per foot). Risk classification based on Belgian guidelines: risk category 3 = Diabetic patient with at least one of the following complications: history of ulceration/peripheral arterial disease, risk category 2b: = diabetic patient with neuropathy and pronounced rigid foot deformities, risk category 2a = diabetic patient with neuropathy and mild/flexible foot deformities, risk category 1 = diabetic patient with neuropathy, risk 0 = diabetic patient without complications as mentioned in other risk categories.

经邦费罗尼校正（Bonferroni correction）后的显著性检验P值阈值为0.05/26=0.002；*针对糖尿病足数量的两两费希尔精确检验显示，聚类簇2与聚类簇3存在显著差异；**针对足部男女性别的两两费希尔精确检验显示，聚类簇2分别与聚类簇3、4存在显著差异。FDS即足部畸形评分（Foot Deformity Score），采用6分量表进行评估，每项特征计1分，涵盖轻度肌肉萎缩、骨性突起、跖骨头突出、锤状/爪状趾、关节活动受限、夏科足畸形（Charcot foot deformity）。（本研究将夏科足设为排除标准，故本次未纳入关节活动受限指标，即祈祷征（prayer sign））。足背动脉搏动评估：采用足背动脉与胫后动脉触诊法。10g单丝感觉测试（Sens Monofil 10 g）：采用单足6分量表评估10g单丝触觉感知情况。风险分级基于比利时临床指南制定：风险等级3为合并至少1项下述并发症的糖尿病患者：溃疡病史/外周动脉疾病（peripheral arterial disease）；风险等级2b为合并神经病变与显著僵硬性足部畸形的糖尿病患者；风险等级2a为合并神经病变与轻度/柔韧性足部畸形的糖尿病患者；风险等级1为仅合并神经病变的糖尿病患者；风险等级0为无上述其他风险分类中提及并发症的糖尿病患者。