Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors. Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors

Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors Overall design: RNA-seq, H3K27Ac ChIP-seq data of MSCs and Ewing Sarcoma and non-Ewing sarcoma cells treated with EWS-ZFA or KRAB-ZFA Two biological replicates for each samples were prepared.

采用工程化锌指转录因子对人类微卫星重复序列进行全基因组功能扰动 实验整体设计：本数据集包含经EWS-ZFA或KRAB-ZFA处理的间充质干细胞（Mesenchymal Stem Cells, MSCs）、尤因肉瘤细胞及非尤因肉瘤细胞的RNA测序（RNA-seq）与组蛋白H3赖氨酸27乙酰化染色质免疫共沉淀测序（H3K27Ac ChIP-seq）数据；所有样本均设置两个生物学重复。