PREVALENCE OF HYPOCALCEMIA AMONG PATIENTS WITH ESSENTIAL HYPERTENSION IN A TERTIARY CARE CENTRE

Background:Hypertension is a leading public health problem in both developed and developing world. About 1.28 million adults aged 30-79yrs worldwide have hypertension andmost of them are living in low and middle income countries. It is the major cause of premature death in world. Every 1 in 5 has their hypertension status under control. It is single important risk factor for cardiovascular disease. Calcium plays an important role in regulating body homeostasis. Association between calcium and hypertension remain uncertain in general population.

Methods:Patients with essential hypertension who attended O.P.D of Internal MedicineDepartmentofTDMedicalCollege,Alappuzhawaschosenasthestudypopulation. Sample size was estimated to be 100. Blood pressure was measured by using standard guidelines and were classified according to JNC-8 guidelines. General and systemic examinations done. Data was entered in excel spreadsheet and analyzed using SPSS software.

Results:Prevalence of Hypercalcemia among essential Hypertension patients was found to be740 per 1000 persons. The totalcorrected serum calcium levels had a significantnegative correlation with the leveland stage of systolic blood pressurein essential hypertensive patients(p value-0.006). The totalcorrected serum calcium levels had nosignificant correlation with the diastolic blood pressure inessential hypertensivepatients. (pvalue-0.088)

Conclusions:Thetotalcorrectedserumcalciumlevelsweresignificantlyloweredinessential hypertensionpatients. Prevalence of Hypocalcemia among essential Hypertension patients was foundtobe740 per 1000 persons.

背景：高血压是发达国家与发展中国家共同面临的首要公共卫生问题。全球约有128万30~79岁成年人罹患高血压，其中多数居住于中低收入国家。高血压是全球过早死亡的主要诱因，仅五分之一患者的高血压病情得到有效控制。其作为心血管疾病的重要单一危险因素，对人群健康危害显著。钙在调节机体稳态过程中发挥关键作用，但普通人群中钙与高血压的关联仍未明确。

方法：选取就诊于阿拉普扎TD医学院内科门诊（O.P.D）的原发性高血压（essential hypertension）患者作为研究人群，经样本量估算最终纳入100例受试者。按照标准指南测量血压，并依据美国高血压联合委员会第八次报告（JNC-8）标准进行血压分级。对所有受试者完成一般体格检查与系统体格检查。数据录入Excel电子表格后，采用SPSS统计软件进行数据分析。

结果：本研究发现，原发性高血压患者的高钙血症（hypercalcemia）患病率为740/1000。校正后总血清钙（total corrected serum calcium）水平与原发性高血压患者的收缩压水平及分期呈显著负相关（p=0.006）；校正后总血清钙水平与原发性高血压患者的舒张压无显著相关性（p=0.088）。

结论：原发性高血压患者的校正后总血清钙水平显著降低。本研究显示，原发性高血压患者的低钙血症（hypocalcemia）患病率为740/1000。