Association(1) of SLC19A2CpG sites with rs6025 (FV Leiden mutation) in the discovery and replication studies.

(1) Association is expressed as methylation β-value mean (SE) in carriers and non-carriers.(2) Reported p-values were those derived from a linear regression model where the probe methylation level was the outcome and the carrier status the covariate, while adjusting for age, sex, batch, chip and cell type composition.Association(1) of SLC19A2CpG sites with rs6025 (FV Leiden mutation) in the discovery and replication studies.

(1) 关联分析以突变携带者与非携带者的甲基化β值(methylation β-value)均值及标准误(Standard Error, SE)进行表征。(2) 报告的p值源自以探针甲基化水平为因变量、携带者状态为协变量的线性回归模型，同时校正了年龄、性别、批次、芯片以及细胞类型组成的混杂效应。前述符合(1)中定义的关联分析，针对发现队列研究(discovery study)与验证队列研究(replication study)中SLC19A2的CpG位点与rs6025（FV Leiden突变(Factor V Leiden mutation)）之间的关联。