Systemic Immune-Inflammatory Index as a Determinant of Atherosclerotic Burden and High-Risk Patients with Acute Coronary Syndromes

Abstract Background Systemic immune-inflammatory index (SII), which is derived from neutrophil, platelet and lymphocyte counts, represents the homeostatic balance among inflammatory, immune and thrombotic status. The systemic immune-inflammatory index is superior to indices such as neutrophil-lymphocyte ratio in predicting prognosis in various malignancies, while it is shown to predict future cardiac events better than traditional risk factors after coronary intervention. Objectives Herein, we aimed to evaluate the relationship of the systemic immune-inflammatory index with atherosclerotic burden and in-hospital complications in acute coronary syndrome patients. Methods The clinical outcomes, such as extent of myocardial damage, atherosclerotic burden, bleeding, acute kidney injury, duration of hospital stay and in-hospital mortality, were evaluated in a retrospective cohort of 309 consecutive acute coronary syndrome patients. The systemic immune-inflammatory index was calculated as (Platelet X Neutrophil)/Lymphocyte count on admission. Study population was categorized into tertiles with regard to systemic immune-inflammatory index. A p value of

摘要 背景
全身免疫炎症指数（Systemic immune-inflammatory index, SII）由中性粒细胞、血小板及淋巴细胞计数计算得到，可反映炎症、免疫与血栓状态间的稳态平衡。该指数在多种恶性肿瘤的预后预测中优于中性粒细胞-淋巴细胞比值等指标，且在冠状动脉介入治疗后，其预测未来心脏不良事件的性能优于传统风险因素。
研究目的
本研究旨在评估急性冠状动脉综合征患者中，全身免疫炎症指数与动脉粥样硬化负荷及院内并发症的关联。
研究方法
本研究对309例连续纳入的急性冠状动脉综合征患者开展回顾性队列分析，评估心肌损伤程度、动脉粥样硬化负荷、出血事件、急性肾损伤、住院时长及院内死亡率等临床结局。全身免疫炎症指数以入院时（血小板计数×中性粒细胞计数）/淋巴细胞计数的公式计算得出。研究对象按全身免疫炎症指数水平被分为三分位组。P值为