Nitric Oxide-LOG Dataset in Inhaled Nitric Oxide Use in Pediatric Intensive Care

This file includes nitric oxide information
Study Description
Acute lung injury (ALI) occurs in approximately 9% of mechanically ventilated children with 80% progressing to acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) is an important therapy for neonates with persistent pulmonary hypertension, older children with pulmonary hypertension, and patients with congenital heart disease. It is hypothesized that iNO should benefit patients with ALI/ARDS by improving oxygenation. With this prospective observational trial, we found that clinician responsiveness to improved oxygenation was associated with less ventilator days. Algorithms to standardize ventilator management may improve signal to noise ratios in future trials enabling better assessment of the effect of inhaled nitric oxide on patient outcomes. Additionally, confining studies to more selective patient populations, such as those with right ventricular dysfunction, may be required. Subjects less than 18 years of age who were mechanically ventilated and received inhaled nitric oxide (iNO) in the PICU or CICU

本数据集包含一氧化氮相关信息。
研究概况
急性肺损伤（ALI）在机械通气儿童中的发生率约为9%，其中80%会进展为急性呼吸窘迫综合征（ARDS）。吸入性一氧化氮（iNO）是治疗持续性肺动脉高压新生儿、合并肺动脉高压的年长儿童以及先天性心脏病患者的重要疗法。本研究提出假说：吸入性一氧化氮可通过改善氧合状态使急性肺损伤/急性呼吸窘迫综合征患者获益。通过此项前瞻性观察性研究，我们发现临床医师对氧合改善的响应与更短的机械通气天数相关。标准化呼吸机管理的算法可提升未来研究中的信噪比，从而更精准地评估吸入性一氧化氮对患者预后的影响。此外，可能需要将研究限定于更具针对性的患者群体，例如合并右心功能不全的人群。本研究的受试者为年龄未满18岁、在儿科重症监护病房（Pediatric Intensive Care Unit，PICU）或心脏重症监护病房（Cardiac Intensive Care Unit，CICU）接受机械通气且接受吸入性一氧化氮（iNO）治疗的患儿。