Transcriptomic changes in wild-type and Phlpp1-/- mice following KLA stimulation

The goals of this study are to compare transcriptome profiling (RNA-seq) of bone marrow derived macrophages from wild-type and PHLPP1 knock-out mice and how Inflammatory stimulation affects those profiles. Overall design: Bone marrow derived mRNA profiles of wild-type and Phlpp1-/- mice were generated in duplicate.

本研究旨在对比野生型（wild-type）与PHLPP1基因敲除小鼠（PHLPP1 knock-out mice）的骨髓来源巨噬细胞（bone marrow derived macrophages）转录组谱分析（transcriptome profiling，RNA-seq）结果，并探究炎症刺激（Inflammatory stimulation）对上述基因表达谱的影响。实验整体设计：针对野生型及Phlpp1-/-小鼠的骨髓来源mRNA表达谱开展了双重复实验。