Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic and antibody protein array study

Abdominal aortic aneurysms (AAA), are defined by an increased aortic diameter and characterized by impairment of the extracellular matrix, macrophages infiltration and decreased density of smooth muscle cells. Our aim is to identify the key molecules involved in the pathogenesis of AAAs. This study investigated transcriptomic and proteomic profiles of macrophages from AAA patients (> 50 mm aortic diameter) and peripheral arterial occlusion (PAO) patients without AAA detected, who both needed a surgery. Transcriptomic profiling data presented here. We tested mRNA from macrophages of 4 different AAA patients and 4 different PAO (peripheral arterial occlusion) samples. RNA sample from each AAA and PAO patients were compared each other.

腹主动脉瘤（abdominal aortic aneurysms, AAA）定义为主动脉直径扩张，其病理特征为细胞外基质受损、巨噬细胞浸润和平滑肌细胞密度降低。本研究旨在明确参与腹主动脉瘤发病机制的关键分子。本研究对两类需接受手术治疗的患者的巨噬细胞转录组与蛋白质组特征展开分析：一类为主动脉直径＞50mm的腹主动脉瘤患者，另一类为未检出腹主动脉瘤的外周动脉闭塞（peripheral arterial occlusion, PAO）患者。本文所呈现的为转录组分析数据。本研究采集了4例腹主动脉瘤患者与4例外周动脉闭塞患者的巨噬细胞mRNA样本，并将每例腹主动脉瘤患者的RNA样本与每例外周动脉闭塞患者的RNA样本进行两两比对分析。