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Background
The COVID-19 pandemic has spread over the world. The ability to achieve sufficient immunization coverage to end the global pandemic depends on the acceptance of the COVID-19 vaccine, but it has faced a major challenge around the world. In low-income and developing countries, 22.7% of the population has received at least one dose of the Covid-19 vaccine, which means that a large percentage of the population are unvaccinated, even though they have access to the Covid-19 vaccine so many countries do not accept the vaccine. The aim of this study was to assess COVID-19 vaccine acceptance and its associated factors in Debre Berhan City, Ethiopia, 2022.
Methods
A mixed-methods approach comprising both qualitative interviews and a quantitative survey was used among participants in Debre Berhan City. A multi-stage sampling technique was used to recruit the study participants. An in-depth interview was used for the qualitative data. Data was collected by a face-to-face interview questionnaire from June 08 to July 08, 2022. The collected data was entered using Epi Data version 4.6 and analyzed using SPSS version 25. Variables with a p-value less than 0.25 at Bivariable logistic regression analysis were entered into multivariable logistic regression analysis. Logistics regression was employed, and a p-value <0.05 was considered statistically significant.
Result
A total of 765 participants were included in the study, with a response rate of 97.08%. More than half (52.9%) of the respondents had the willingness to accept the COVID-19 vaccine. Participants who had Contact with COVID-19 patient (AOR = 3.98; 95% CI: (1.30–12.14), having good knowledge of COVID-19 vaccine (AOR = 4.63; 95% CI: (1.84–11.63), and positive attitude toward the COVID-19 vaccine (AOR = 3.41; 95% CI: (1.34–8.69) were statistically significantly associated variables with COVID-19 vaccine acceptance.
Conclusion and recommendation
The present study revealed that the acceptance COVID-19 vaccine was 52.9, and a significant proportion of participants were hesitant to receive the vaccine and refused to get vaccinated. Significantly associated Variables for COVID-19 vaccine acceptance were Contact with COVID-19 patient, having good knowledge of the COVID-19 vaccine, and having a positive attitude towards the COVID-19 vaccine. Various stakeholders to apprise the public about the cause of the disease and the scientific development of vaccine in order to enhance acceptance of the vaccine.

研究背景
新冠疫情已在全球范围内蔓延。终结全球新冠大流行所需的充足免疫覆盖率，有赖于民众对新冠疫苗的接受意愿，但全球各地均面临这一核心挑战。在低收入与发展中国家，仅22.7%的人口完成至少一剂新冠疫苗接种，这意味着仍有大量人口未完成疫苗接种——尽管诸多国家已可获取新冠疫苗，但不少民众拒绝接种。本研究旨在评估2022年埃塞俄比亚德布雷贝尔汉市（Debre Berhan City）居民的新冠疫苗接受意愿及其相关影响因素。

研究方法
本研究采用混合研究方法，结合质性访谈与定量问卷调查，研究对象选自埃塞俄比亚德布雷贝尔汉市。研究招募采用多阶段抽样技术。质性数据收集采用深入访谈法。研究数据于2022年6月8日至7月8日通过面对面访谈式问卷采集，使用Epi Data 4.6版进行数据录入，采用SPSS 25版完成统计分析。将二元logistic回归分析中P值<0.25的变量纳入多因素logistic回归分析。本研究采用logistic回归模型，以P<0.05作为统计学显著性判定标准。

研究结果
本研究共纳入765名参与者，应答率达97.08%。超过半数（52.9%）的受访者表示愿意接种新冠疫苗。与新冠患者有接触史（调整后优势比[AOR]=3.98；95%置信区间[CI]：1.30~12.14）、对新冠疫苗具备良好认知（AOR=4.63；95%CI：1.84~11.63）以及对新冠疫苗持有积极态度（AOR=3.41；95%CI：1.34~8.69）的参与者，其新冠疫苗接受意愿与上述因素存在显著统计学关联。

结论与建议
本研究结果显示，当地新冠疫苗接受意愿率为52.9%，仍有相当比例的参与者对疫苗接种持犹豫或拒绝态度。与新冠疫苗接受意愿显著相关的因素包括：与新冠患者有接触史、对新冠疫苗具备良好认知以及对新冠疫苗持有积极态度。建议各相关利益主体向公众普及新冠疾病相关知识与疫苗研发的科学原理，以提升民众的疫苗接受意愿。