GRA HPA Axis Supplementary Tables and Stats

We hypothesized that the chronic administration of the novel GR receptor modulator CORT113176 during chronic sleep restriction (SR) and opioid abstinence would reveal important effects on the HPA axis giving insight into mechanisms of the interaction of SR and opioid abstinence. We concluded that the response of the HPA axis to CORT113176 during SR and opioid abstinence is not predictable by sex or sleep state because it can act both as an antagonist and agonist in the brain and pituitary, and an agonist in the adrenal gland in a sexually dimorphic manner.

我们提出如下假说：在慢性睡眠限制（chronic sleep restriction, SR）与阿片类药物戒断期间，长期给予新型糖皮质激素受体（glucocorticoid receptor, GR）调节剂CORT113176，可揭示其对下丘脑-垂体-肾上腺轴（hypothalamic-pituitary-adrenal axis, HPA axis）的关键调控效应，从而为解析慢性睡眠限制与阿片类戒断的相互作用机制提供重要洞见。本研究最终得出结论：慢性睡眠限制与阿片类戒断期间，下丘脑-垂体-肾上腺轴对CORT113176的响应无法通过性别或睡眠状态进行预测——该调节剂可在大脑与垂体中同时发挥拮抗剂与激动剂的双重活性，并在肾上腺中以性别二态性的方式行使激动剂功能。