Heidelberg BAG (HeidelBAG)

The HeidelBAG unifies structural efforts of EMBL Heidelberg inclusive former PIs and the Heidelberg University Biochemistry Center (BZH). Central to all projects are large assemblies involved in chromosome organization and transcription control, in nuclear and cytoplasmic RNA regulation, in translational control by ribosome associated factors, in protein targeting and membrane protein insertion, or in post-translational and RNA modification and processing. Nearly all projects make use of integrated structural biology techniques (MX, SAXS/SANS, NMR, cryo-EM) combined with complementary biophysical approaches. MX remains the essential and invariant tool for high resolution information of challenging functional modules.

HeidelBAG整合了欧洲分子生物学实验室海德堡分部（EMBL Heidelberg，含前首席研究员（Principal Investigator，PI））与海德堡大学生物化学中心（Heidelberg University Biochemistry Center, BZH）的结构生物学研究工作。所有项目的核心研究对象为参与多种生命过程的大型复合物：涵盖染色体组织与转录调控、细胞核与细胞质内的RNA调控、核糖体关联因子介导的翻译调控、蛋白质靶向递送与膜蛋白插入，以及翻译后修饰、RNA修饰与加工等过程。几乎所有项目均整合使用结构生物学技术（MX、SAXS/SANS、NMR、冷冻电镜（cryo-EM）），并辅以互补的生物物理研究方法。其中，MX仍是获取挑战性功能模块高分辨率结构信息的核心且不可或缺的工具。