DUSP11-mediated Control of 5’-Triphosphate RNA Regulates RIG-I Sensitivity

Mice lacking DUSP11 display enhanced interferon signaling signature RNA extracted from liver (n=24) or spleen (n=6) of wild-type (n=15) and DUSP11-deficient (n=15) mice subjected to immune-stimulatory 5'-ppp RNA treatment (n=12 liver, 8 male/4 female), mock treatment (n=6 liver, 2 male/4 female; n=6 spleen, 2 male/4 female), or untreated (n=6 liver, 4 male/2 female). Mice were age/sex pair-matched within each treatment.

缺失DUSP11基因的小鼠呈现增强的干扰素信号通路特征。本数据集的RNA样本提取自野生型与DUSP11缺陷型小鼠的肝脏（总样本量n=24）或脾脏（总样本量n=6），其中野生型小鼠共15只，DUSP11缺陷型小鼠共15只。受试小鼠接受三类处理：免疫刺激性5'-三磷酸（5'-ppp）RNA处理（肝脏样本n=12，含雄性8只、雌性4只）、模拟空白对照处理（肝脏样本n=6，雄性2只、雌性4只；脾脏样本n=6，雄性2只、雌性4只），以及未处理组（肝脏样本n=6，雄性4只、雌性2只）。所有处理组内的小鼠均按年龄与性别进行配对匹配。