Lineage-specific mapping of quantitative trait loci

We present an approach for quantitative trait locus (QTL) mapping, termed \"lineage-specific QTL mapping\", for inferring allelic changes of QTL evolution along branches in a phylogeny. We describe and analyze the simplest case: by adding a third taxon into the normal procedure of QTL mapping between pairs of taxa, such inferences can be made along lineages to a presumed common ancestor. While comparisons of QTL maps among species can identify homology of QTLs by apparent co-location, lineage specific mapping of QTL can classify homology into (1) orthology (shared origin of QTL) versus (2) paralogy (independent origin of QTL within resolution of map distance). In this light, we present a graphical method that identifies six modes of QTL evolution in a three taxon comparison. We then apply our model to map lineage-specific QTLs for inbreeding among three taxa of yellow monkeyflower: Mimulus guttatus and two inbreeders M. platycalyx and M. micranthus, but critically assuming outcrossing was...

我们提出一种数量性状位点（QTL）定位方法，称为“谱系特异性QTL定位”，用于推断系统发育树分支上QTL进化的等位基因变化。我们描述并分析了最简单的情况：通过在成对分类群间的常规QTL定位流程中加入第三个分类群，即可沿谱系向假定的共同祖先进行此类推断。虽然物种间QTL图谱的比较可通过明显的共定位识别QTL的同源性，但谱系特异性QTL定位能将同源性分为（1）直系同源（QTL的共同起源）与（2）旁系同源（在图谱距离分辨率内QTL的独立起源）两类。基于此，我们提出一种图形化方法，可在三分类群比较中识别QTL进化的六种模式。随后，我们将该模型应用于黄色猴面花三个分类群（沟酸浆Mimulus guttatus及两个近交类群M. platycalyx和M. micranthus）的近交性状谱系特异性QTL定位，但关键假设异交曾...