Effect of salbutamol on the cardiovascular response in healthy subjects at rest, during physical exercise, and in recovery phase: a randomized, double-blind, crossover study

ABSTRACT Aim To evaluate the effect of the short-acting beta agonists (SABAs) salbutamol on cardiovascular response rest, exercise and recovery phase. Methods This study was conducted as a randomized, double-blind, placebo controlled, crossover study in 15 healthy adults, with a mean age of 30.2±6.6 years. Participants underwent a maximal effort test on two non-consecutive days with 400 mcg of salbutamol or placebo. Throughout the protocol, the variables HR, blood pressure (BP), perceived rate of effort (modified Borg scale) and peak expiratory flow (PEF) were monitored. Results After salbutamol, baseline HR and PEF had increase from 71±8 to 80±11 bpm (p<0.05) and 454.0±64.5 to 475.3±71.4 L/min (p < 0.05), respectively. The variables HR, BP and Borg were similar between interventions during all the protocol phases (p>0.05). Conclusion Administration of salbutamol increased rest heart rate; however, did not change heart rate, blood pressure and perceived exertion during exercise or recovery. This suggests that the salbutamol administration is safe and does not affect exercise intensity prescription in healthy subjects.

摘要 研究目的：评估短效β受体激动剂（short-acting beta agonists，SABAs）沙丁胺醇对静息状态、运动阶段及恢复阶段心血管反应的影响。方法：本研究采用随机、双盲、安慰剂对照交叉设计，纳入15名健康成年人，平均年龄为30.2±6.6岁。受试者在两个非连续天数内分别接受400μg沙丁胺醇或安慰剂干预，并完成最大负荷试验。整个试验流程中，对心率（heart rate，HR）、血压（blood pressure，BP）、自觉劳累程度评分（改良Borg量表）以及峰流速（peak expiratory flow，PEF）等各项指标进行监测。结果：给予沙丁胺醇后，受试者的静息基线心率与峰流速分别从71±8次/分钟升高至80±11次/分钟（p<0.05），以及从454.0±64.5 L/min升高至475.3±71.4 L/min（p<0.05）。在试验的所有阶段，两种干预方式下的心率、血压及自觉劳累程度评分均无显著差异（p>0.05）。结论：沙丁胺醇给药可升高静息心率，但不会改变运动及恢复阶段的心率、血压与自觉劳累程度。这提示，健康人群使用沙丁胺醇具有安全性，且不会影响运动强度的处方制定。