Vaccine-induced antigen-specific CD4+ T cell response.

The mean values of the total responses (Env, Gag and Pol) are shown. A) Frequency of Env-specific CD4+ T cells (B) Frequency of Gag-specific CD4+ T cells. (C) Frequency of Pol-specific CD4+ T cells. The box plots show the distribution of responses in positive responders only. The boxes indicate the median (solid line), mean (dashed line), and interquartile range (IQR). P values were determined using Mann-Whitney T test. (Note: P-Placebo, T2-Prevaccination, T3-Second week after first MVA vaccination, T4-Second week after last MVA vaccination).