Host-pathogen interactions during Staphylococcus aureus bovine mastitis in MAC-T cells and in mice infection model and characterization of main Canadian spa-types

Staphylococcus aureus is the main pathogen leading to both acute or subclinical bovine mastitis in dairy cattle. . Prediction of disease evolution based on the characteristics of the S. aureus strains and host/pathogen interactions studies would greatly help management of dairy herds. For this study, at least three S. aureus isolates from each of the major Canadian spa types associated with mastitis were selected and investigated in infection models. Moreover, their genomic traits such as virulence genes and phylogenetic relationship were characterized.

金黄色葡萄球菌（Staphylococcus aureus）是引发奶牛急性与亚临床型乳房炎的主要病原菌。基于该菌株特性以及宿主-病原体互作研究来预测疾病转归，将对奶牛群的管理提供重要助力。本研究针对与乳房炎相关的加拿大主流spa分型（spa types），每个分型均选取至少3株金黄色葡萄球菌分离株，在感染模型中开展实验研究。此外，还对这些菌株的毒力基因、系统发育关系等基因组特征进行了表征分析。