Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

Human herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics.

人类单纯疱疹病毒（Human herpes simplex viruses，HSV）1型与2型的分型通常借助分子检测手段完成。本研究首次报道了一例因UL27基因（编码糖蛋白B的基因）中此前未被发现的HSV-1与HSV-2重组事件引发的HSV分型错误案例。这也是首次有报道称HSV发生种间重组并影响该基因——该基因常被用作诊断检测与实验性治疗的靶标。