Development of Chiral Pincer Palladium Complexes Bearing a Pyrroloimidazolone Unit. Catalytic Use for Asymmetric Michael Addition

Novel pincer palladium complexes having chiral hexahydro-1H-pyrrolo[1,2-c]imidazolone groups were designed and prepared. Catalytic asymmetric
Michael addition of isopropyl 2-cyanopropionate to ethyl vinyl ketone was catalyzed by the chiral pincer palladium complex to give isopropyl
2-cyano-2-methyl-5-oxoheptanoate with high enantioselectivity (up to 83% ee).

设计并合成了一类带有手性六氢-1H-吡咯并[1,2-c]咪唑啉酮基团的新型钳形钯配合物。该手性钳形钯配合物可催化2-氰基丙酸异丙酯与乙烯基乙基酮的不对称迈克尔加成反应，得到2-氰基-2-甲基-5-氧代庚酸异丙酯，产物具有高对映选择性，对映体过量值（ee）最高可达83%。