Supplementary_material: Prognostic significance and function of minichromosome maintenance protein 10 in human hepatocellular carcinoma.docx

<b>Supplementary
Figure 1</b>
<b>Data for MCM10
expression in HCC from online databases.</b> (<b>A</b>) The
transcription level of MCM10 in 20 different types of human cancers
(ONCOMINE). Color is determined by the highest gene rank percentile genes
based on log fold-change; red represents upregulation and blue indicates
downregulation. Cut-off of <i>P</i>-value and fold change were as following: <i>P</i>-value:
0.05, fold change: 1.5, gene rank: 10%, data type: mRNA. (<b>B</b>) Relative
expression of MCM10 in HCC tissues (n = 371) and adjacent normal liver
tissues (n = 50) from TCGA database (UALCAN). (<b>C</b>) Relative expression
of MCM10 in normal individuals (n = 50) and in HCC patients with different
cancer stages (Stage 1, n = 168; Stage 2, n = 84; Stage 3, n = 82; Stage 4, n
= 6). *<i>P</i> &lt; 0.05, **<i>P</i> &lt; 0.01, ***<i>P</i> &lt; 0.001. (<b>D</b>)
Representative immunohistochemistry images of MCM10 protein in HCC tissues
and normal liver tissues (Human Protein Atlas).
<b> </b>
<b>Supplementary Table 1 </b>
Clinicopathological
characteristics of 364 HCC patients.

<b>Supplementary Table
2 </b>
Estimated
AUC value of TNM and MCM10 in 364 HCC patients after follow-up.

<b>Supplementary Table
3 </b>
Summary
of significantly enriched GO annotations of MCM10 related network.

<b>补充图1</b>
<b>肝细胞癌（HCC）中MCM10表达的在线数据库数据</b>。(<b>A</b>) MCM10在20种不同类型人类癌症中的转录水平（ONCOMINE数据库）。颜色由基于对数倍数变化的最高基因排名百分位基因决定；红色代表上调，蓝色代表下调。<i>P</i>值和倍数变化的cutoff值设置如下：<i>P</i>值：0.05，倍数变化：1.5，基因排名：10%，数据类型：mRNA。(<b>B</b>) 来自TCGA数据库（UALCAN平台）的肝细胞癌（HCC）组织（n=371）与癌旁正常肝组织（n=50）中MCM10的相对表达水平。(<b>C</b>) 正常个体（n=50）与不同分期肝细胞癌（HCC）患者（1期：168例；2期：84例；3期：82例；4期：6例）中MCM10的相对表达水平。*<i>P</i> < 0.05，**<i>P</i> < 0.01，***<i>P</i> < 0.001。(<b>D</b>) 肝细胞癌（HCC）组织与正常肝组织中MCM10蛋白的代表性免疫组化图像（人类蛋白质图谱数据库）。

<b>补充表1</b>
364例肝细胞癌（HCC）患者的临床病理特征。

<b>补充表2</b>
364例肝细胞癌（HCC）患者随访后TNM分期与MCM10的估计AUC值。

<b>补充表3</b>
MCM10相关网络显著富集的基因本体（GO）注释总结。