Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2

Acute myeloid leukemia (AML) is a type of heterogeneous and fatal hematopoietic malignancy. The ten-eleven translocation (TET) mediated DNA demethylation is known to be critically associated with AML pathogenesis. Here we studied the therapeutic function of opioid receptor agonists in AML, and revealed the OPRM1-TET1 regulatory axis in AML response to the agonists. All sequencing data (including RNA-seq, ChIP-seq, 5hmC-seq and 5mC-seq, etc.) and other raw data are included.

急性髓系白血病（Acute myeloid leukemia, AML）是一类异质性且致死性的造血系统恶性肿瘤。已有研究表明，十-十一易位（ten-eleven translocation, TET）介导的DNA去甲基化与AML的发病机制密切相关。本研究探讨了阿片受体激动剂在AML中的治疗功能，并揭示了AML细胞响应此类激动剂的OPRM1-TET1调控轴。本数据集包含所有测序相关原始数据（涵盖RNA测序（RNA-seq）、染色质免疫共沉淀测序（ChIP-seq）、5-羟甲基胞嘧啶测序（5hmC-seq）与5-甲基胞嘧啶测序（5mC-seq）等）及其他原始实验数据。