Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation (BiSulfite-seq)

DNA methylation analysis of T-cell acute lymphoblastic leukemia blast cells from either control mice or Dnmt3a knockout mice carrying a Notch1 Intracellular Domain (NICD) retrovirus Overall design: Comparison of DNA methylation between control and Dnmt3a-KO NICD-driven T-ALL

本数据集针对两类T细胞急性淋巴细胞白血病（T-cell acute lymphoblastic leukemia, T-ALL）母细胞开展DNA甲基化分析，其来源分别为对照小鼠，以及携带Notch1胞内结构域（Notch1 Intracellular Domain, NICD）逆转录病毒的Dnmt3a敲除小鼠。整体实验设计：对比对照组与Dnmt3a敲除、NICD诱导的T-ALL样本之间的DNA甲基化水平差异。