Unfavorable triglyceride-rich particle profile in subclinical thyroid disease: A cross-sectional analysis of ELSA-Brasil

Introduction: Subclinical thyroid disorders have been associated with atherosclerosis and increased cardiovascular risk. As triglyceride-rich lipoprotein particles (TRLP) have recently emerged as a casual factor for atherogenesis, the aim of this study was to evaluate the relationship between subclinical hypo and hyperthyroidism and TRLP subfractions.

Methods: We selected 5,066 participants from the ELSA-Brasil cohort with available data of thyroid function and lipid profile measured by NMR. Individuals were divided into three groups by baseline thyroid function (subclinical hypothyroidism, euthyroidism, and subclinical hyperthyroidism). TRLP subfractions were analyzed through Nuclear Magnetic Resonance (NMR) spectroscopy. To examine the association between TRLP subfractions and thyroid function, we conducted univariate and multivariate linear regression models adjusted for demographic characteristics, BMI, diabetes, smoking status and alcohol use.

Results: Of 3,304 individuals, 5...

引言：亚临床甲状腺疾病（Subclinical thyroid disorders）与动脉粥样硬化及心血管风险增加相关。鉴于富含甘油三酯的脂蛋白颗粒（triglyceride-rich lipoprotein particles, TRLP）近期被证实是动脉粥样硬化发生的危险因素，本研究旨在评估亚临床甲状腺功能减退与亢进状态与TRLP亚组分之间的关联。

方法：本研究从ELSA-Brasil队列中筛选出5066名参与者，其甲状腺功能数据及经核磁共振（Nuclear Magnetic Resonance, NMR）检测的脂质谱数据均完整可用。根据基线甲状腺功能状态，参与者被分为三组：亚临床甲状腺功能减退组、甲状腺功能正常组及亚临床甲状腺功能亢进组。TRLP亚组分通过核磁共振（NMR）波谱法进行分析。为探究TRLP亚组分与甲状腺功能之间的关联，本研究采用单变量及多变量线性回归模型，并对人口统计学特征、体重指数（Body Mass Index, BMI）、糖尿病、吸烟状态及饮酒情况进行校正。

结果：在3304名个体中，5...