Role and efficacy of the ironized anti-PD1 inhibitors in antitumor immunity in hepatocellular carcinoma. Role and efficacy of the ironized anti-PD1 inhibitors in antitumor immunity in hepatocellular carcinoma

The inherently therapeutic nanomedicine can alter and augment immune response in liver cancer, potentially leading to the development of a new family of combination immunotherapy. Overall design: BNL-MEA tumor-bearing Balb/c mice treated with vehicle, anti-PD1, and ironized anti-PD1

本研究使用的固有治疗性纳米药物（nanomedicine）可调节并增强肝癌的免疫应答，有望催生新型联合免疫疗法家族。实验整体设计：将携带BNL-MEA肿瘤的Balb/c小鼠分为三组，分别给予赋形剂、抗PD-1（anti-PD1）以及铁修饰抗PD-1（ironized anti-PD1）处理。