Table_4_Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis.docx

BackgroundSerum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.
MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.
ResultsOverall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = −0.506, 95%CI = −0.674 to −0.338, p < 0.001), HDL-c (WMD = −0.122, 95%CI = −0.205 to −0.039, p = 0.004), and LDL-c (WMD = −0.371, 95%CI = −0.547 to −0.194, p < 0.001) levels. CD groups had a significantly lower TC (WMD = −0.349, 95%CI = −0.528 to −0.170, p < 0.0001) level as compared to UC groups. Active IBD and non-mild UC groups had significantly lower TC (WMD = −0.454, 95%CI = −0.722 to −0.187, p = 0.001) (WMD =0.462, 95%CI = 0.176 to 0.748, p = 0.002) and LDL-c (WMD = −0.225, 95%CI = −0.445 to −0.005, p = 0.045) (WMD =0.346, 95%CI = 0.084–0.609, p = 0.010) levels as compared to inactive IBD and mild UC groups, respectively.
ConclusionThe overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.
Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.

背景
炎症性肠病（Inflammatory Bowel Disease, IBD）患者的血清脂质水平往往存在异常。然而，不同研究中IBD患者血清脂质异常的具体表型存在异质性，目前尚未得到充分明确。

方法
本研究检索了PubMed、EMBASE及Cochrane Library数据库。分别对比了IBD患者与健康个体、克罗恩病（Crohn’s Disease, CD）与溃疡性结肠炎（Ulcerative Colitis, UC）患者、活动期与缓解期患者、轻度与非轻度患者的血清脂质水平。采用随机效应模型进行Meta分析，计算加权均数差（Weight Mean Difference, WMD）及其95%置信区间（Confidence Interval, CI）。

结果
最终共纳入53项研究。与健康对照相比，IBD患者的总胆固醇（Total Cholesterol, TC）、高密度脂蛋白胆固醇（High-Density Lipoprotein Cholesterol, HDL-c）及低密度脂蛋白胆固醇（Low-Density Lipoprotein Cholesterol, LDL-c）水平均显著降低（TC：WMD=-0.506，95%CI：-0.674~-0.338，p<0.001；HDL-c：WMD=-0.122，95%CI：-0.205~-0.039，p=0.004；LDL-c：WMD=-0.371，95%CI：-0.547~-0.194，p<0.001）。克罗恩病组的TC水平较溃疡性结肠炎组显著降低（WMD=-0.349，95%CI：-0.528~-0.170，p<0.0001）。与缓解期IBD患者及轻度UC患者相比，活动期IBD患者与非轻度UC患者的TC及LDL-c水平分别呈现显著差异：活动期IBD患者的TC水平显著低于缓解期IBD患者（WMD=-0.454，95%CI：-0.722~-0.187，p=0.001），LDL-c水平亦显著降低（WMD=-0.225，95%CI：-0.445~-0.005，p=0.045）；非轻度UC患者的TC水平显著高于轻度UC患者（WMD=0.462，95%CI：0.176~0.748，p=0.002），LDL-c水平亦显著升高（WMD=0.346，95%CI：0.084~0.609，p=0.010）。

结论
IBD患者的整体血清脂质水平低于健康人群，且与疾病严重程度呈负相关。

系统评价注册
https://www.crd.york.ac.uk/prospero/，注册编号：CRD42022383885。