Data Sheet 4_Global, regional and national burden of polycystic ovary syndrome: historical trends from 1990 to 2021 and projections to 2035.doc

BackgroundThis study aims to deepen the understanding and assessment of the global burden of polycystic ovary syndrome (PCOS), providing a basis for policy-making and resource allocation to help achieve global health goals.
MethodsThis study focused on analyzing the disease burden of PCOS at the global, regional, and national levels, considering age factors and predicting trends up to 2035. This study also involved cross-national inequality analysis, frontier analysis, and decomposition analysis.
ResultsThe burden of PCOS is increasing, with the age of onset concentrated in the 10–19 age group, while the number of cases and DALYs is predominantly in the 15–49 age group. Countries with a higher Socio-demographic Index (SDI) bear a heavier burden of PCOS, effectively controlling its growth trend. Inequality persists. Population growth and epidemiological changes are driving the increase in the burden of PCOS. By 2035, the burden of PCOS is projected to continue increasing.
ConclusionThe global burden of PCOS shows an overall increasing trend, with significant differences among different regions and countries. Greater support is needed for low SDI to standardize diagnostic criteria, raise public health awareness, and better protect women’s health.

背景：本研究旨在深化对多囊卵巢综合征（polycystic ovary syndrome, PCOS）全球疾病负担的认知与评估，为政策制定与资源配置提供依据，助力实现全球健康目标。方法：本研究聚焦于全球、区域及国家层面的多囊卵巢综合征疾病负担分析，纳入年龄维度因素，并预测至2035年的疾病负担趋势。本研究同时开展了跨国不平等分析、前沿分析与分解分析。结果：多囊卵巢综合征的疾病负担呈上升趋势，发病年龄集中于10~19岁年龄段，而病例数与伤残调整寿命年（Disability-Adjusted Life Years, DALYs）主要集中于15~49岁年龄段。社会人口学指数（Socio-demographic Index, SDI）较高的国家多囊卵巢综合征疾病负担更重，且可有效遏制疾病负担的增长态势，但跨国不平等问题依然存在。人口增长与流行病学变化是推动多囊卵巢综合征疾病负担上升的主要因素。预计至2035年，多囊卵巢综合征的疾病负担仍将持续攀升。结论：全球多囊卵巢综合征疾病负担整体呈上升趋势，不同区域与国家间存在显著差异。需为社会人口学指数较低的地区提供更多支持，以统一诊断标准、提升公众健康认知，并更好地保护女性健康。